Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors

Mutations within Ras proteins represent major drivers in human cancer. In this study, we report the structure-based design, synthesis, as well as biochemical and cellular evaluation of nucleotide-based covalent inhibitors for KRasG13C, an important oncogenic mutant of Ras that has not been successfu...

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Detalles Bibliográficos
Autores principales: Goebel, Lisa, Kirschner, Tonia, Koska, Sandra, Rai, Amrita, Janning, Petra, Maffini, Stefano, Vatheuer, Helge, Czodrowski, Paul, Goody, Roger S, Müller, Matthias P, Rauh, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042540/
https://www.ncbi.nlm.nih.gov/pubmed/36972177
http://dx.doi.org/10.7554/eLife.82184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042540/
https://www.ncbi.nlm.nih.gov/pubmed/36972177
http://dx.doi.org/10.7554/eLife.82184

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