SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways

Endogenous metabolites, environmental agents, and therapeutic drugs promote formation of covalent DNA-protein crosslinks (DPCs). Persistent DPCs compromise genome integrity and are eliminated by multiple repair pathways. Aberrant Top1-DNA crosslinks, or Top1ccs, are processed by Tdp1 and Wss1 functi...

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Detalles Bibliográficos
Autores principales: Serbyn, Nataliia, Bagdiul, Ivona, Noireterre, Audrey, Michel, Agnès H., Suhandynata, Raymond T., Zhou, Huilin, Kornmann, Benoît, Stutz, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042627/
https://www.ncbi.nlm.nih.gov/pubmed/34818558
http://dx.doi.org/10.1016/j.celrep.2021.110034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042627/
https://www.ncbi.nlm.nih.gov/pubmed/34818558
http://dx.doi.org/10.1016/j.celrep.2021.110034

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