Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling

BACKGROUND: Site-of-action concentrations for bedaquiline and pretomanid from tuberculosis patients are unavailable. The objective of this work was to predict bedaquiline and pretomanid site-of-action exposures using a translational minimal physiologically based pharmacokinetic (mPBPK) approach to u...

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Detalles Bibliográficos
Autores principales: Mehta, Krina, Guo, Tingjie, van der Graaf, Piet H., van Hasselt, J. G. Coen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042768/
https://www.ncbi.nlm.nih.gov/pubmed/36802057
http://dx.doi.org/10.1007/s40262-023-01217-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042768/
https://www.ncbi.nlm.nih.gov/pubmed/36802057
http://dx.doi.org/10.1007/s40262-023-01217-7

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