Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)

A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was used to detect the cytotoxic effect of the novel chalcones against lung cancer cell line (A549). Molecular docking studies were per...

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Autores principales: Mohamed, Magda F., Ibrahim, Nada S., Saddiq, Amna A., Almaghrabi, Omar A., Al-Hazemi, Maha E., Hassaneen, Hamdi M., Abdelhamid, Ismail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042774/
https://www.ncbi.nlm.nih.gov/pubmed/36469109
http://dx.doi.org/10.1007/s00210-022-02344-x
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author Mohamed, Magda F.
Ibrahim, Nada S.
Saddiq, Amna A.
Almaghrabi, Omar A.
Al-Hazemi, Maha E.
Hassaneen, Hamdi M.
Abdelhamid, Ismail A.
author_facet Mohamed, Magda F.
Ibrahim, Nada S.
Saddiq, Amna A.
Almaghrabi, Omar A.
Al-Hazemi, Maha E.
Hassaneen, Hamdi M.
Abdelhamid, Ismail A.
author_sort Mohamed, Magda F.
collection PubMed
description A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was used to detect the cytotoxic effect of the novel chalcones against lung cancer cell line (A549). Molecular docking studies were performed on the most two effective chalcones 7b and 7c. Different molecular techniques were utilized to study the activity and the effect of two chalcones 7b and 7c on apoptosis of A549 cell line. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00210-022-02344-x.
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spelling pubmed-100427742023-03-29 Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549) Mohamed, Magda F. Ibrahim, Nada S. Saddiq, Amna A. Almaghrabi, Omar A. Al-Hazemi, Maha E. Hassaneen, Hamdi M. Abdelhamid, Ismail A. Naunyn Schmiedebergs Arch Pharmacol Research A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was used to detect the cytotoxic effect of the novel chalcones against lung cancer cell line (A549). Molecular docking studies were performed on the most two effective chalcones 7b and 7c. Different molecular techniques were utilized to study the activity and the effect of two chalcones 7b and 7c on apoptosis of A549 cell line. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00210-022-02344-x. Springer Berlin Heidelberg 2022-12-05 2023 /pmc/articles/PMC10042774/ /pubmed/36469109 http://dx.doi.org/10.1007/s00210-022-02344-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Mohamed, Magda F.
Ibrahim, Nada S.
Saddiq, Amna A.
Almaghrabi, Omar A.
Al-Hazemi, Maha E.
Hassaneen, Hamdi M.
Abdelhamid, Ismail A.
Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
title Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
title_full Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
title_fullStr Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
title_full_unstemmed Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
title_short Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
title_sort theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (a549)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042774/
https://www.ncbi.nlm.nih.gov/pubmed/36469109
http://dx.doi.org/10.1007/s00210-022-02344-x
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