The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology

In Parkinson’s disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying aSyn pathology are still unclear, but they are hypothesized to involve the autophagy-lysosome pathway (ALP). LRRK2 mutations...

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Detalles Bibliográficos
Autores principales: Obergasteiger, Julia, Castonguay, Anne-Marie, Pizzi, Sara, Magnabosco, Stefano, Frapporti, Giulia, Lobbestael, Evy, Baekelandt, Veerle, Hicks, Andrew A., Pramstaller, Peter P., Gravel, Claude, Corti, Corrado, Lévesque, Martin, Volta, Mattia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042831/
https://www.ncbi.nlm.nih.gov/pubmed/36973269
http://dx.doi.org/10.1038/s41531-023-00484-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042831/
https://www.ncbi.nlm.nih.gov/pubmed/36973269
http://dx.doi.org/10.1038/s41531-023-00484-2

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