Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

Diabetic cardiomyopathy (DCM) is characterized by lipid accumulation, mitochondrial dysfunction, and aseptic inflammatory activation. Mitochondria-derived cytosolic DNA has been reported to induce inflammation by activating cyclic GMP-AMP synthase (cGAS)/the stimulator of interferon genes (STING) pa...

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Detalles Bibliográficos
Autores principales: Ma, Xiu Mei, Geng, Kang, Law, Betty Yuen-Kwan, Wang, Peng, Pu, Yue Li, Chen, Qing, Xu, Hui Wen, Tan, Xiao Zhen, Jiang, Zong Zhe, Xu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042943/
https://www.ncbi.nlm.nih.gov/pubmed/35235096
http://dx.doi.org/10.1007/s10565-021-09692-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042943/
https://www.ncbi.nlm.nih.gov/pubmed/35235096
http://dx.doi.org/10.1007/s10565-021-09692-z

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