PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response

PARP1 (aka ARTD1) acts as a prime sensor of cellular genotoxic stress response. PARP1 detects DNA strand breaks and subsequently catalyzes the formation of poly(ADP-ribose) (PAR), which leads to the recruitment of the scaffold protein XRCC1 during base excision and single strand break repair and the...

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Detalles Bibliográficos
Autores principales: Reber, Julia M., Božić-Petković, Jovana, Lippmann, Michelle, Mazzardo, Marvin, Dilger, Asisa, Warmers, Rebecca, Bürkle, Alexander, Mangerich, Aswin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042965/
https://www.ncbi.nlm.nih.gov/pubmed/35778544
http://dx.doi.org/10.1007/s10565-022-09739-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042965/
https://www.ncbi.nlm.nih.gov/pubmed/35778544
http://dx.doi.org/10.1007/s10565-022-09739-9

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