PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia

Sildenafil is a potent vasodilator and phosphodiesterase type five inhibitor, commercially known as Revatio(®) and approved for the treatment of pulmonary arterial hypertension. Maternal administration of sildenafil during pregnancy is being evaluated for antenatal treatment of several conditions, i...

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Detalles Bibliográficos
Autores principales: Macente, Julia, Nauwelaerts, Nina, Russo, Francesca M., Deprest, Jan, Allegaert, Karel, Lammens, Bart, Hernandes Bonan, Rodolfo, Turner, Jessica M., Kumar, Sailesh, Diniz, Andrea, Martins, Frederico S., Annaert, Pieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043195/
https://www.ncbi.nlm.nih.gov/pubmed/36998614
http://dx.doi.org/10.3389/fphar.2023.1068153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043195/
https://www.ncbi.nlm.nih.gov/pubmed/36998614
http://dx.doi.org/10.3389/fphar.2023.1068153

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