Cargando…

PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia

Sildenafil is a potent vasodilator and phosphodiesterase type five inhibitor, commercially known as Revatio(®) and approved for the treatment of pulmonary arterial hypertension. Maternal administration of sildenafil during pregnancy is being evaluated for antenatal treatment of several conditions, i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Macente, Julia, Nauwelaerts, Nina, Russo, Francesca M., Deprest, Jan, Allegaert, Karel, Lammens, Bart, Hernandes Bonan, Rodolfo, Turner, Jessica M., Kumar, Sailesh, Diniz, Andrea, Martins, Frederico S., Annaert, Pieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043195/ https://www.ncbi.nlm.nih.gov/pubmed/36998614 http://dx.doi.org/10.3389/fphar.2023.1068153

Ejemplares similares

Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project
por: Nauwelaerts, Nina, et al.
Publicado: (2023)

Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study
por: Russo, Francesca Maria, et al.
Publicado: (2018)

Challenges Related to Acquisition of Physiological Data for Physiologically Based Pharmacokinetic (PBPK) Models in Postpartum, Lactating Women and Breastfed Infants—A Contribution from the ConcePTION Project
por: Van Neste, Martje, et al.
Publicado: (2023)

Case Report: Bosentan and Sildenafil Exposure in Human Milk - A Contribution From the ConcePTION Project
por: Nauwelaerts, Nina, et al.
Publicado: (2022)

Use of sildenafil in late postoperative period of congenital diaphragmatic hernia
por: Falcão, Mário Cícero, et al.
Publicado: (2021)

The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia
por: Cochius-den Otter, Suzan, et al.
Publicado: (2019)

Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
por: De Bie, Felix Rafael, et al.
Publicado: (2022)

Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia
por: Deprest, J.A., et al.
Publicado: (2021)

Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats
por: Yoshida, Shiho, et al.
Publicado: (2023)

Antenatal Assessment of the Prognosis of Congenital Diaphragmatic Hernia: Ethical Considerations and Impact for the Management
por: Le Duc, Kévin, et al.
Publicado: (2022)

Challenges and Pitfalls: Performing Clinical Trials in Patients With Congenital Diaphragmatic Hernia
por: Cochius - den Otter, Suzan, et al.
Publicado: (2022)

Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia
por: Okolo, Frances C., et al.
Publicado: (2018)

Diaphragmatic Hernia
por: Adams, Jas. A.
Publicado: (1880)

Diaphragmatic Hernia
Publicado: (1878)

EMERGING ANTENATAL THERAPIES FOR CONGENITAL DIAPHRAGMATIC HERNIA-INDUCED PULMONARY HYPERTENSION IN PRECLINICAL MODELS
por: Marulanda, Kathleen, et al.
Publicado: (2020)

Fetoscopic endoluminal tracheal occlusion and reestablishment of fetal airways for congenital diaphragmatic hernia
por: Van der Veeken, Lennart, et al.
Publicado: (2018)

A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates
por: Smits, Anne, et al.
Publicado: (2020)

Fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia: a narrative review of the history, current practice, and future directions
por: Perrone, Erin E., et al.
Publicado: (2021)

Intrapericardial Diaphragmatic Hernia
por: Heiner, Jason D., et al.
Publicado: (2010)

Congenital Diaphragmatic Hernia
por: Tovar, Juan A
Publicado: (2012)

Paraœsophageal Diaphragmatic Hernia
Publicado: (1928)

Spontaneous Diaphragmatic Hernia
por: Darocki, Mark D., et al.
Publicado: (2018)

Case of Diaphragmatic Hernia
por: Robertson, J. Hinton
Publicado: (1929)

Congenital diaphragmatic hernia
por: Dalton, Heidi J.
Publicado: (2017)

Genetics of diaphragmatic hernia
por: Schreiner, Yannick, et al.
Publicado: (2021)

Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia
por: Deprest, Jan A., et al.
Publicado: (2021)

Creatinine Trends and Patterns in Neonates Undergoing Whole Body Hypothermia: A Systematic Review
por: Borloo, Noor, et al.
Publicado: (2021)

Prenatal treprostinil reduces the pulmonary hypertension phenotype in the rat model of congenital diaphragmatic hernia
por: De Bie, Felix Rafael, et al.
Publicado: (2022)

The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs
por: Nguyen, Tram Mai, et al.
Publicado: (2019)

QTc Intervals Are Prolonged in Late Preterm and Term Neonates during Therapeutic Hypothermia but Normalize Afterwards
por: Allegaert, Karel, et al.
Publicado: (2021)

Bilateral Congenital Diaphragmatic Hernia
por: Dhua, Anjan kumar, et al.
Publicado: (2012)

Case of Strangulated Diaphragmatic Hernia
por: Macfadyen, James
Publicado: (1823)

Two Cases of Diaphragmatic Hernia
por: Cruickshank, M. M.
Publicado: (1935)

Giant left diaphragmatic hernia
por: Voskens, F J, et al.
Publicado: (2021)

Traumatic intrapericardial diaphragmatic hernia
por: Okamoto, Soichiro, et al.
Publicado: (2023)

Correction: The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs
por: Nguyen, Tram Mai, et al.
Publicado: (2019)

Study protocol: a core outcome set for perinatal interventions for congenital diaphragmatic hernia
por: Vergote, Simen, et al.
Publicado: (2021)

Assessment of Antenatal and Postnatal Prognostic Indicators in the Outcome of Neonatal Congenital Diaphragmatic Hernia: A Prospective Observational Study
por: Deivasigamani, Aniruthan, et al.
Publicado: (2023)

Laparoscopic diaphragmatic hernia repair using expanded polytetrafluoroethylene (ePTFE) for delayed traumatic diaphragmatic hernia
por: Jee, Yeseob
Publicado: (2017)

Pulmonary transcriptome analysis in the surgically induced rabbit model of diaphragmatic hernia treated with fetal tracheal occlusion
por: Engels, Alexander C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8ring2e88haf13ui1atapbefgf