Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes

INTRODUCTION: While Yap and Wwtr1 regulate resident cardiac fibroblast to myofibroblast differentiation following cardiac injury, their role specifically in activated myofibroblasts remains unexplored. METHODS: We assessed the pathophysiological and cellular consequence of genetic depletion of Yap a...

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Detalles Bibliográficos
Autores principales: Flinn, Michael A., Alvarez-Argote, Santiago, Knas, Makenna C., Almeida, Victor Alencar, Paddock, Samantha J., Zhou, Xiaoxu, Buddell, Tyler, Jamal, Ayana, Taylor, Reiauna, Liu, Pengyuan, Drnevich, Jenny, Patterson, Michaela, Link, Brian A., O’Meara, Caitlin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043314/
https://www.ncbi.nlm.nih.gov/pubmed/36998974
http://dx.doi.org/10.3389/fcvm.2023.1142612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043314/
https://www.ncbi.nlm.nih.gov/pubmed/36998974
http://dx.doi.org/10.3389/fcvm.2023.1142612

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