Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

INTRODUCTION: The leukemia inhibitory factor (LIF), is a cytokine belonging to IL-6 family, whose overexpression correlate with poor prognosis in cancer patients, including pancreatic ductal adenocarcinoma (PDAC). LIF signaling is mediate by its binding to the heterodimeric LIF receptor (LIFR) compl...

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Detalles Bibliográficos
Autores principales: Di Giorgio, Cristina, Bellini, Rachele, Lupia, Antonio, Massa, Carmen, Bordoni, Martina, Marchianò, Silvia, Rosselli, Rosalinda, Sepe, Valentina, Rapacciuolo, Pasquale, Moraca, Federica, Morretta, Elva, Ricci, Patrizia, Urbani, Ginevra, Monti, Maria Chiara, Biagioli, Michele, Distrutti, Eleonora, Catalanotti, Bruno, Zampella, Angela, Fiorucci, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043345/
https://www.ncbi.nlm.nih.gov/pubmed/36998446
http://dx.doi.org/10.3389/fonc.2023.1140730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043345/
https://www.ncbi.nlm.nih.gov/pubmed/36998446
http://dx.doi.org/10.3389/fonc.2023.1140730

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