Evaluation of limited-sampling strategies to calculate AUC((0–24)) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus

Background: Kidney transplantation (KTx) requires immunosuppressive drugs such as Tacrolimus (TAC) which is mainly metabolized by CYP3A5. TAC is routinely monitored by trough levels (C(0)) although it has not shown to be a reliable marker. The area-under-curve (AUC) is a more realistic measure of dr...

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Detalles Bibliográficos
Autores principales: Galvez, Carla, Boza, Pía, González, Mariluz, Hormazabal, Catalina, Encina, Marlene, Azócar, Manuel, Castañeda, Luis E., Rojo, Angélica, Ceballos, María Luisa, Krall, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043346/
https://www.ncbi.nlm.nih.gov/pubmed/36998611
http://dx.doi.org/10.3389/fphar.2023.1044050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043346/
https://www.ncbi.nlm.nih.gov/pubmed/36998611
http://dx.doi.org/10.3389/fphar.2023.1044050

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