A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge

Influenza virosomes serve as antigen delivery vehicles and pre-existing immunity toward influenza improves the immune responses toward antigens. Here, vaccine efficacy was evaluated in non-human primates with a COVID-19 virosome-based vaccine containing a low dose of RBD protein (15 µg) and the adju...

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Detalles Bibliográficos
Autores principales: Koopman, Gerrit, Amacker, Mario, Stegmann, Toon, Verschoor, Ernst J., Verstrepen, Babs E., Bhoelan, Farien, Bemelman, Denzel, Böszörményi, Kinga P., Fagrouch, Zahra, Kiemenyi-Kayere, Gwendoline, Mortier, Daniella, Verel, Dagmar E., Niphuis, Henk, Acar, Roja Fidel, Kondova, Ivanela, Kap, Yolanda S., Bogers, Willy M. J. M., Mooij, Petra, Fleury, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044094/
https://www.ncbi.nlm.nih.gov/pubmed/36977691
http://dx.doi.org/10.1038/s41598-023-31818-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044094/
https://www.ncbi.nlm.nih.gov/pubmed/36977691
http://dx.doi.org/10.1038/s41598-023-31818-y

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