Cargando…

A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge

Influenza virosomes serve as antigen delivery vehicles and pre-existing immunity toward influenza improves the immune responses toward antigens. Here, vaccine efficacy was evaluated in non-human primates with a COVID-19 virosome-based vaccine containing a low dose of RBD protein (15 µg) and the adju...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koopman, Gerrit, Amacker, Mario, Stegmann, Toon, Verschoor, Ernst J., Verstrepen, Babs E., Bhoelan, Farien, Bemelman, Denzel, Böszörményi, Kinga P., Fagrouch, Zahra, Kiemenyi-Kayere, Gwendoline, Mortier, Daniella, Verel, Dagmar E., Niphuis, Henk, Acar, Roja Fidel, Kondova, Ivanela, Kap, Yolanda S., Bogers, Willy M. J. M., Mooij, Petra, Fleury, Sylvain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044094/ https://www.ncbi.nlm.nih.gov/pubmed/36977691 http://dx.doi.org/10.1038/s41598-023-31818-y

Ejemplares similares

Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2
por: Mooij, Petra, et al.
Publicado: (2022)

Insect Cells for High-Yield Production of SARS-CoV-2 Spike Protein: Building a Virosome-Based COVID-19 Vaccine Candidate
por: Fernandes, Bárbara, et al.
Publicado: (2022)

The Post-Acute Phase of SARS-CoV-2 Infection in Two Macaque Species Is Associated with Signs of Ongoing Virus Replication and Pathology in Pulmonary and Extrapulmonary Tissues
por: Böszörményi, Kinga P., et al.
Publicado: (2021)

Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies
por: Deuzing, Ilona, et al.
Publicado: (2010)

A Bacterially-Expressed Recombinant Envelope Protein from Usutu Virus Induces Neutralizing Antibodies in Rabbits
por: Böszörményi, Kinga, et al.
Publicado: (2021)

Enhanced HPV16 E6/E7(+) tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides
por: Stegmann, Toon, et al.
Publicado: (2023)

Aerosolized Exposure to H5N1 Influenza Virus Causes Less Severe Disease Than Infection via Combined Intrabronchial, Oral, and Nasal Inoculation in Cynomolgus Macaques
por: Mooij, Petra, et al.
Publicado: (2021)

New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes
por: Amacker, Mario, et al.
Publicado: (2020)

Complete Genome Sequence of a Novel Chimpanzee Polyomavirus from a Western Common Chimpanzee
por: van Persie, Jolanda, et al.
Publicado: (2016)

Vaccine-Induced Protection of Rhesus Macaques against Plasma Viremia after Intradermal Infection with a European Lineage 1 Strain of West Nile Virus
por: Verstrepen, Babs E., et al.
Publicado: (2014)

Novel application of [(18)F]DPA714 for visualizing the pulmonary inflammation process of SARS-CoV-2-infection in rhesus monkeys (Macaca mulatta)
por: Meijer, Lisette, et al.
Publicado: (2022)

Experimental Infection of Rhesus Macaques and Common Marmosets with a European Strain of West Nile Virus
por: Verstrepen, Babs E., et al.
Publicado: (2014)

Pandemic Swine-Origin H1N1 Influenza Virus Replicates to Higher Levels and Induces More Fever and Acute Inflammatory Cytokines in Cynomolgus versus Rhesus Monkeys and Can Replicate in Common Marmosets
por: Mooij, Petra, et al.
Publicado: (2015)

Strong Vaccine-Induced CD8 T-Cell Responses Have Cytolytic Function in a Chimpanzee Clearing HCV Infection
por: Verstrepen, Babs E., et al.
Publicado: (2014)

Retrospective Serology Study of Respiratory Virus Infections in Captive Great Apes
por: Buitendijk, Hester, et al.
Publicado: (2014)

Safety and immunogenicity of four-segmented Rift Valley fever virus in the common marmoset
por: Wichgers Schreur, Paul J., et al.
Publicado: (2022)

Development of a Virosomal RSV Vaccine Containing 3D-PHAD® Adjuvant: Formulation, Composition, and Long-Term Stability
por: Lederhofer, J., et al.
Publicado: (2018)

A novel inactivated virus system (InViS) for a fast and inexpensive assessment of viral disintegration
por: Furer, Lea A., et al.
Publicado: (2022)

Absence of accessory genes in a divergent simian T-lymphotropic virus type 1 isolated from a bonnet macaque (Macaca radiata)
por: Afonso, Philippe V., et al.
Publicado: (2019)

Protection in Macaques Immunized with HIV-1 Candidate Vaccines Can Be Predicted Using the Kinetics of Their Neutralizing Antibodies
por: Davis, David, et al.
Publicado: (2011)

Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against Plasmodium falciparum parasites in preclinical in vitro and in vivo models
por: Tamborrini, Marco, et al.
Publicado: (2020)

Immunogenicity of a virosomally-formulated Plasmodium falciparum GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to adjuvanted formulations
por: Tamborrini, Marco, et al.
Publicado: (2011)

Virosome: An engineered virus for vaccine delivery
por: Ali, Hasan, et al.
Publicado: (2023)

A Triple Co-Culture Model of the Human Respiratory Tract to Study Immune-Modulatory Effects of Liposomes and Virosomes
por: Blom, Rebecca A. M., et al.
Publicado: (2016)

Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees
por: Verstrepen, Babs E., et al.
Publicado: (2012)

Bronchoalveolar lavage affects thorax computed tomography of healthy and SARS-CoV-2 infected rhesus macaques (Macaca mulatta)
por: Maaskant, Annemiek, et al.
Publicado: (2021)

Pulmonary Delivery of Virosome-Bound Antigen Enhances Antigen-Specific CD4(+) T Cell Proliferation Compared to Liposome-Bound or Soluble Antigen
por: Blom, Rebecca A. M., et al.
Publicado: (2017)

Immunogenicity and Protective Capacity of a Virosomal Respiratory Syncytial Virus Vaccine Adjuvanted with Monophosphoryl Lipid A in Mice
por: Kamphuis, Tobias, et al.
Publicado: (2012)

P04-25. Exposure of HIV-1 pseudovirus to soluble CD4 increases the breadth of neutralization with sera from macaques immunized with recombinant glycoproteins
por: Davis, D, et al.
Publicado: (2009)

A Capsid Virus-Like Particle-Based SARS-CoV-2 Vaccine Induces High Levels of Antibodies and Protects Rhesus Macaques
por: Volkmann, Ariane, et al.
Publicado: (2022)

Brain Inflammation and Intracellular α-Synuclein Aggregates in Macaques after SARS-CoV-2 Infection
por: Philippens, Ingrid H. C. H. M., et al.
Publicado: (2022)

Scalable Process for High-Yield Production of PfCyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate
por: Fernandes, Bárbara, et al.
Publicado: (2022)

P19-02. High protection of female macaques from repeated intravaginal challenges with SHIV-162P3 upon mucosal vaccination with Gp41 subunits-virosomes
por: Bomsel, M, et al.
Publicado: (2009)

Insights on the functional interactions between miRNAs and copy number variations in the aging brain
por: Persengiev, Stephan, et al.
Publicado: (2013)

Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques
por: Nieuwland, Juliana M., et al.
Publicado: (2023)

Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes
por: Leroux-Roels, Geert, et al.
Publicado: (2013)

Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1
por: Persengiev, Stephan, et al.
Publicado: (2012)

Virosome Presents Multimodel Cancer Therapy without Viral Replication
por: Saga, Kotaro, et al.
Publicado: (2013)

Serological evidence of coronavirus infections in native hamadryas baboons (Papio hamadryas hamadryas) of the Kingdom of Saudi Arabia
por: OLARINMOYE, A.O., et al.
Publicado: (2017)

In Vitro Neutralization of Low Dose Inocula at Physiological Concentrations of a Monoclonal Antibody Which Protects Macaques against SHIV Challenge
por: Davis, David, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ij6rnhtf33rs01rtrnjebkvnec