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Allosteric inhibition of TEM‐1 β lactamase: Microsecond molecular dynamics simulations provide mechanistic insights
β‐lactam antibiotics target DD‐transpeptidases, enzymes that perform the last step of bacterial cell‐wall synthesis. To block the antimicrobial activity of these antibiotics, bacteria have evolved lactamases that render them inert. Among these, TEM‐1, a class A lactamase, has been extensively studie...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044111/ https://www.ncbi.nlm.nih.gov/pubmed/36906819 http://dx.doi.org/10.1002/pro.4622 |