The in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652

1. In vitro incubation of the bacterial β-glucuronidase inhibitor UNC10201652 (4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4′,5′:4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine) with mouse, rat, and human liver microsomes and hepatocytes generated metabolites at multiple sites via deethyla...

Descripción completa

Detalles Bibliográficos
Autores principales: Kerins, Anna, Koszyczarek, Marta, Smith, Caroline, Butler, Phil, Riley, Rob, Madgula, Vamsi, Naik, Nilkanth, Redinbo, Matthew R., Wilson, Ian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044449/
https://www.ncbi.nlm.nih.gov/pubmed/36149349
http://dx.doi.org/10.1080/00498254.2022.2128468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044449/
https://www.ncbi.nlm.nih.gov/pubmed/36149349
http://dx.doi.org/10.1080/00498254.2022.2128468

Ejemplares similares