Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficacy of β-Lactam Antibiotics

Class A serine β-lactamases (SBLs) have a conserved non-active site structural domain called the omega loop (Ω-loop), in which a glutamic acid residue is believed to be directly involved in the hydrolysis of β-lactam antibiotics by providing a water molecule during catalysis. We aimed to design and...

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Detalles Bibliográficos
Autores principales: Biswal, Sarmistha, Caetano, Karina, Jain, Diamond, Sarrila, Anusha, Munshi, Tulika, Dickman, Rachael, Tabor, Alethea B., Rath, Surya Narayan, Bhakta, Sanjib, Ghosh, Anindya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044640/
https://www.ncbi.nlm.nih.gov/pubmed/36978420
http://dx.doi.org/10.3390/antibiotics12030553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044640/
https://www.ncbi.nlm.nih.gov/pubmed/36978420
http://dx.doi.org/10.3390/antibiotics12030553

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