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APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine deaminases involved in innate and adaptive immunity. However, some APOBEC family members can also deaminate host genomes to generate oncogenic mutations. The resulting mutations, primarily signatures 2 and 13, occur...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044795/ https://www.ncbi.nlm.nih.gov/pubmed/36978147 http://dx.doi.org/10.1186/s13045-023-01425-5 |