Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

Loss-of-function (LOF) mutations in GRN gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not fully understood. Mitochondrial dysfunction has bee...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodríguez-Periñán, Guiomar, de la Encarnación, Ana, Moreno, Fermín, López de Munain, Adolfo, Martínez, Ana, Martín-Requero, Ángeles, Alquézar, Carolina, Bartolomé, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044829/
https://www.ncbi.nlm.nih.gov/pubmed/36978829
http://dx.doi.org/10.3390/antiox12030581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044829/
https://www.ncbi.nlm.nih.gov/pubmed/36978829
http://dx.doi.org/10.3390/antiox12030581

Ejemplares similares