Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition

Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition of glutathione peroxidase 4 (GPX4), a key intracellular antioxidant re...

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Detalles Bibliográficos
Autores principales: Gleitze, Silvia, Ramírez, Omar A., Vega-Vásquez, Ignacio, Yan, Jing, Lobos, Pedro, Bading, Hilmar, Núñez, Marco T., Paula-Lima, Andrea, Hidalgo, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045106/
https://www.ncbi.nlm.nih.gov/pubmed/36978954
http://dx.doi.org/10.3390/antiox12030705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045106/
https://www.ncbi.nlm.nih.gov/pubmed/36978954
http://dx.doi.org/10.3390/antiox12030705

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