In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes

Type II transmembrane serine proteases represent pharmacological targets for blocking entry and spread of influenza or coronaviruses. In this study, the depletion rates of the 3-amidinophenylalanine (3-APhA)-derived matriptase/TMPRSS2 inhibitors MI-463, MI-472, MI-485 or MI-1900 were determined by L...

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Detalles Bibliográficos
Autores principales: Lányi, Katalin, Monostory, Katalin, Steinmetzer, Torsten, Jerzsele, Ákos, Pászti-Gere, Erzsébet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045298/
https://www.ncbi.nlm.nih.gov/pubmed/36979660
http://dx.doi.org/10.3390/biomedicines11030682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045298/
https://www.ncbi.nlm.nih.gov/pubmed/36979660
http://dx.doi.org/10.3390/biomedicines11030682

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