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Protective Potential of β-Hydroxybutyrate against Glucose-Deprivation-Induced Neurotoxicity Involving the Modulation of Autophagic Flux and the Monomeric Aβ Level in Neuro-2a Cells

Hypoglycemia has been known as a potential contributory factor to neurodegenerative diseases, such as Alzheimer’s disease. There may be shared pathogenic mechanisms underlying both conditions, and the ketone body, β-hydroxybutyrate (BHB), as an alternative substrate for glucose may exert neuroprotec...

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Detalles Bibliográficos
Autores principales: Chiang, Yi-Fen, Nguyen, Ngan Thi Kim, Hsia, Shih-Min, Chen, Hsin-Yuan, Lin, Shyh-Hsiang, Lin, Ching-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045359/
https://www.ncbi.nlm.nih.gov/pubmed/36979677
http://dx.doi.org/10.3390/biomedicines11030698