PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in Drosophila Models

Charcot–Marie–Tooth disease (CMT) is a group of inherited peripheral nerve disorders characterized by progressive muscle weakness and atrophy, sensory loss, foot deformities and steppage gait. Missense mutations in the gene encoding the small heat shock protein HSPB8 (HSP22) have been associated wit...

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Detalles Bibliográficos
Autores principales: Kang, Kyong-hwa, Han, Ji Eun, Kim, Hyunjin, Kim, Sohee, Hong, Young Bin, Yun, Jeanho, Nam, Soo Hyun, Choi, Byung-Ok, Koh, Hyongjong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045361/
https://www.ncbi.nlm.nih.gov/pubmed/36979812
http://dx.doi.org/10.3390/biomedicines11030832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045361/
https://www.ncbi.nlm.nih.gov/pubmed/36979812
http://dx.doi.org/10.3390/biomedicines11030832

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