Exacerbated Neuropathy in POLAR A and M Trials Due to Redox Interaction of PledOx-Associated Mn(2+) and Oxaliplatin-Associated Pt(2+)

Disappointing results from the POLAR A and M phase III trials involving colorectal cancer patients on chemotherapy with FOLFOX6 in curative (A) and palliative (M) settings have been reported by the principal investigators and the sponsor (PledPharma AB/Egetis Therapeutics AB). FOLFOX6, oxaliplatin i...

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Detalles Bibliográficos
Autores principales: Karlsson, Jan Olof G., Jynge, Per, Ignarro, Louis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045419/
https://www.ncbi.nlm.nih.gov/pubmed/36978857
http://dx.doi.org/10.3390/antiox12030608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045419/
https://www.ncbi.nlm.nih.gov/pubmed/36978857
http://dx.doi.org/10.3390/antiox12030608

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