Auranofin Synergizes with the PARP Inhibitor Olaparib to Induce ROS-Mediated Cell Death in Mutant p53 Cancers

Auranofin (AF) is a potent, off-patent thioredoxin reductase (TrxR) inhibitor that efficiently targets cancer via reactive oxygen species (ROS)- and DNA damage-mediated cell death. The goal of this study is to enhance the efficacy of AF as a cancer treatment by combining it with the poly(ADP-ribose)...

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Detalles Bibliográficos
Autores principales: Freire Boullosa, Laurie, Van Loenhout, Jinthe, Flieswasser, Tal, Hermans, Christophe, Merlin, Céline, Lau, Ho Wa, Marcq, Elly, Verschuuren, Marlies, De Vos, Winnok H., Lardon, Filip, Smits, Evelien L. J., Deben, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045521/
https://www.ncbi.nlm.nih.gov/pubmed/36978917
http://dx.doi.org/10.3390/antiox12030667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045521/
https://www.ncbi.nlm.nih.gov/pubmed/36978917
http://dx.doi.org/10.3390/antiox12030667

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