Cargando…
NEK1-Mediated Phosphorylation of YAP1 Is Key to Prostate Cancer Progression
The key to preventing mCRPC progression is understanding how androgen-dependent PCa cells progress to independence and modify their transcriptional repertoire accordingly. We recently identified a novel axis of the Hippo pathway characterized by the sequential kinase cascade induced by androgen depr...
Autores principales: | Ghosh, Ishita, Khalil, Md Imtiaz, Mirza, Rusella, King, Judy, Olatunde, Damilola, De Benedetti, Arrigo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045622/ https://www.ncbi.nlm.nih.gov/pubmed/36979713 http://dx.doi.org/10.3390/biomedicines11030734 |
Ejemplares similares
-
NEK1 Phosphorylation of YAP Promotes Its Stabilization and Transcriptional Output
por: Khalil, Md Imtiaz, et al.
Publicado: (2020) -
The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1
por: Singh, Vibha, et al.
Publicado: (2020) -
TLK1‐mediated MK5‐S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies
por: Khalil, Md Imtiaz, et al.
Publicado: (2022) -
Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors
por: Singh, Vibha, et al.
Publicado: (2019) -
Interaction of TLK1 and AKTIP as a Potential Regulator of AKT Activation in Castration-Resistant Prostate Cancer Progression
por: Khalil, Md Imtiaz, et al.
Publicado: (2021)