Current sequence-based models capture gene expression determinants in promoters but mostly ignore distal enhancers

BACKGROUND: The largest sequence-based models of transcription control to date are obtained by predicting genome-wide gene regulatory assays across the human genome. This setting is fundamentally correlative, as those models are exposed during training solely to the sequence variation between human...

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Detalles Bibliográficos
Autores principales: Karollus, Alexander, Mauermeier, Thomas, Gagneur, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045630/
https://www.ncbi.nlm.nih.gov/pubmed/36973806
http://dx.doi.org/10.1186/s13059-023-02899-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045630/
https://www.ncbi.nlm.nih.gov/pubmed/36973806
http://dx.doi.org/10.1186/s13059-023-02899-9

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