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Current sequence-based models capture gene expression determinants in promoters but mostly ignore distal enhancers
BACKGROUND: The largest sequence-based models of transcription control to date are obtained by predicting genome-wide gene regulatory assays across the human genome. This setting is fundamentally correlative, as those models are exposed during training solely to the sequence variation between human...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045630/ https://www.ncbi.nlm.nih.gov/pubmed/36973806 http://dx.doi.org/10.1186/s13059-023-02899-9 |