In Vivo Ca(V)3 Channel Inhibition Promotes Maturation of Glucose-Dependent Ca(2+) Signaling in Human iPSC-Islets

Ca(V)3 channels are ontogenetically downregulated with the maturation of certain electrically excitable cells, including pancreatic β cells. Abnormally exaggerated Ca(V)3 channels drive the dedifferentiation of mature β cells. This led us to question whether excessive Ca(V)3 channels, retained mista...

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Detalles Bibliográficos
Autores principales: Zhao, Kaixuan, Shi, Yue, Yu, Jia, Yu, Lina, Köhler, Martin, Mael, Amber, Kolton, Anthony, Joyce, Thomas, Odorico, Jon, Berggren, Per-Olof, Yang, Shao-Nian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045717/
https://www.ncbi.nlm.nih.gov/pubmed/36979793
http://dx.doi.org/10.3390/biomedicines11030807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045717/
https://www.ncbi.nlm.nih.gov/pubmed/36979793
http://dx.doi.org/10.3390/biomedicines11030807

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