Cargando…

Bag-1 Protects Nucleus Pulposus Cells from Oxidative Stress by Interacting with HSP70

Bcl-2-associated athanogene 1 (Bag-1) is a multifunctional prosurvival protein that binds to several intracellular targets and promotes cell survival. HSP70 and Raf-1 are important targets of Bag-1; however, the protective function of Bag-1 in nucleus pulposus (NP) cells remains unclear. In this stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suyama, Kaori, Sakai, Daisuke, Hayashi, Shogo, Qu, Ning, Terayama, Hayato, Kiyoshima, Daisuke, Nagahori, Kenta, Watanabe, Masahiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045753/ https://www.ncbi.nlm.nih.gov/pubmed/36979842 http://dx.doi.org/10.3390/biomedicines11030863

Ejemplares similares

Effects of interleukin‐17A in nucleus pulposus cells and its small‐molecule inhibitors for intervertebral disc disease
por: Suyama, Kaori, et al.
Publicado: (2018)

Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro
por: Nukaga, Tadashi, et al.
Publicado: (2019)

Changes in Expression of Specific mRNA Transcripts after Single- or Re-Irradiation in Mouse Testes
por: Nagahori, Kenta, et al.
Publicado: (2022)

Effect of Neonicotinoid Pesticides on Japanese Water Systems: Review with Focus on Reproductive Toxicity
por: Terayama, Hayato, et al.
Publicado: (2022)

Co-Administration of the Traditional Medicines Hachimi-Jio-Gan and Hochu-Ekki-To Can Reverse Busulfan-Induced Aspermatogenesis
por: Qu, Ning, et al.
Publicado: (2020)

Gosha-Jinki-Gan Recovers Spermatogenesis in Mice with Busulfan-Induced Aspermatogenesis
por: Qu, Ning, et al.
Publicado: (2018)

The effectiveness of traditional Japanese medicine Goshajinkigan in irradiation-induced aspermatogenesis in mice
por: Takahashi, Kumpei, et al.
Publicado: (2019)

CCN family member 2/connective tissue growth factor (CCN2/CTGF) is regulated by Wnt–β-catenin signaling in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2018)

Effect of Gosha-Jinki-Gan on Levels of Specific mRNA Transcripts in Mouse Testes after Busulfan Treatment
por: Qu, Ning, et al.
Publicado: (2020)

Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review
por: Volleman, Tibo Nico Emmie, et al.
Publicado: (2020)

Pathological effect of arterial ischaemia and venous congestion on rat testes
por: Hirai, Shuichi, et al.
Publicado: (2017)

The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review
por: Suyama, Kaori, et al.
Publicado: (2022)

Investigation of the Mitigation of DMSO-Induced Cytotoxicity by Hyaluronic Acid following Cryopreservation of Human Nucleus Pulposus Cells
por: Munesada, Daiki, et al.
Publicado: (2023)

Association of NAT2 genetic polymorphism with the efficacy of Neurotropin® for the enhancement of aggrecan gene expression in nucleus pulposus cells: a pilot study
por: Nakai, Tomoko, et al.
Publicado: (2021)

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species
por: Sakai, Daisuke, et al.
Publicado: (2018)

Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells
por: Sako, Kosuke, et al.
Publicado: (2021)

The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2012)

A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2013)

HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3
por: Hu, Binwu, et al.
Publicado: (2022)

Upregulation of glycosaminoglycan synthesis by Neurotropin in nucleus pulposus cells via stimulation of chondroitin sulfate N-acetylgalactosaminyltransferase 1: A new approach to attenuation of intervertebral disc degeneration
por: Sakai, Daisuke, et al.
Publicado: (2018)

Effect of Cryopreservation on Canine and Human Activated Nucleus Pulposus Cells: A Feasibility Study for Cell Therapy of the Intervertebral Disc
por: Tanaka, Masahiro, et al.
Publicado: (2013)

Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGFβ-1 in cultured rat nucleus pulposus cells
por: Nakai, Tomoko, et al.
Publicado: (2008)

Hsp70 Cochaperones HspBP1 and BAG-1M Differentially Regulate Steroid Hormone Receptor Function
por: Knapp, Regina T., et al.
Publicado: (2014)

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells
por: Tekari, Adel, et al.
Publicado: (2016)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

GRP78 Suppresses Lipid Peroxidation and Promotes Cellular Antioxidant Levels in Glial Cells following Hydrogen Peroxide Exposure
por: Suyama, Kaori, et al.
Publicado: (2014)

Correction to: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells
por: Tekari, Adel, et al.
Publicado: (2019)

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks
por: Meister-Broekema, Melanie, et al.
Publicado: (2018)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass production
por: Tamagawa, Shota, et al.
Publicado: (2022)

The anatomical features of the lateral femoral cutaneous nerve with total hip arthroplasty: a comparative study of direct anterior and anterolateral supine approaches
por: Ukai, Taku, et al.
Publicado: (2022)

Variation in origin of the long head of the biceps brachii tendon in a cadaver: A case report
por: Katsuki, Shuji, et al.
Publicado: (2018)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone
por: Terayama, Hayato, et al.
Publicado: (2016)

HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages
por: Zhang, Shuo, et al.
Publicado: (2022)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health
por: Suyama, Kaori, et al.
Publicado: (2016)

Fusion protein analysis reveals the precise regulation between Hsp70 and Hsp100 during protein disaggregation
por: Hayashi, Sayaka, et al.
Publicado: (2017)

The BAG Homology Domain of Snl1 Cures Yeast Prion [URE3] Through Regulation of Hsp70 Chaperones
por: Kumar, Navinder, et al.
Publicado: (2014)

Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex
por: Evans, Lindsay E., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t3cq6mmtdv9rd56a43ahl93q45