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LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions

BACKGROUND: Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases. However, whether the immunoproteasome itself deficiency causes brain disease is still unclear. Therefore, the aim of t...

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Detalles Bibliográficos
Autores principales: Chen, Xingyong, Mao, Yanguang, Guo, Yueting, Xiao, Dongyun, Lin, Zejing, Huang, Yiyi, Liu, Ying Chun, Zhang, Xu, Wang, Yinzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045813/
https://www.ncbi.nlm.nih.gov/pubmed/36978132
http://dx.doi.org/10.1186/s12967-023-04071-0