Michael Adduct of Sulfonamide Chalcone Targets Folate Metabolism in Brugia Malayi Parasite

A series of Michael adducts of malononitrile and sulfonamide chalcones were synthesized, characterized, and evaluated for their antifilarial activity. Out of 14 compounds, N-(4-(4,4-dicyano-3-p-tolylbutanoyl)phenyl)benzenesulfonamide showed favorable drug-likeness properties with marked antifilarial...

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Detalles Bibliográficos
Autores principales: Bhoj, Priyanka S., Bahekar, Sandeep P., Chowdhary, Shambhavi, Togre, Namdev S., Amdare, Nitin P., Jena, Lingaraj, Goswami, Kalyan, Chandak, Hemant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045823/
https://www.ncbi.nlm.nih.gov/pubmed/36979702
http://dx.doi.org/10.3390/biomedicines11030723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045823/
https://www.ncbi.nlm.nih.gov/pubmed/36979702
http://dx.doi.org/10.3390/biomedicines11030723

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