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ERK-estrogen receptor α signaling plays a role in the process of bone marrow mesenchymal stem cell-derived exosomes protecting against ovariectomy-induced bone loss

BACKGROUND: Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) are considered as candidates for osteoporosis (OP) therapy. Estrogen is critical in the maintenance of bone homeostasis. However, the role of estrogen and/or its receptor in BMSC-Exos treatment of OP, as well as its met...

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Detalles Bibliográficos
Autores principales: Qi, Hui, Shen, Enpu, Shu, Xiong, Liu, Danping, Wu, Cheng’ai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045825/
https://www.ncbi.nlm.nih.gov/pubmed/36973789
http://dx.doi.org/10.1186/s13018-023-03660-5