FGFR2c Upregulation Contributes to Cancer-Associated Fibroblast Program Activation and to Enhanced Autophagy in Actinic Keratosis-Derived Dermal Fibroblasts: A Possible Role in Precancerous Cell/Stromal Cell Crosstalk

SIMPLE SUMMARY: In this work, we checked the possible tumor-promoting role of the mesenchymal FGFR2c isoform when overexpressed in AK stromal fibroblasts. We found that already starting from the early AK lesions, the dermal expression of FGFR2c is upregulated and accompanied by: (i) the repression o...

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Detalles Bibliográficos
Autores principales: Guttieri, Luisa, Raffa, Salvatore, Salerno, Gerardo, Bigi, Rachele, Persechino, Flavia, Visco, Vincenzo, Torrisi, Maria Rosaria, Ranieri, Danilo, Belleudi, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045898/
https://www.ncbi.nlm.nih.gov/pubmed/36979155
http://dx.doi.org/10.3390/biology12030463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045898/
https://www.ncbi.nlm.nih.gov/pubmed/36979155
http://dx.doi.org/10.3390/biology12030463

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