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FGFR2c Upregulation Contributes to Cancer-Associated Fibroblast Program Activation and to Enhanced Autophagy in Actinic Keratosis-Derived Dermal Fibroblasts: A Possible Role in Precancerous Cell/Stromal Cell Crosstalk
SIMPLE SUMMARY: In this work, we checked the possible tumor-promoting role of the mesenchymal FGFR2c isoform when overexpressed in AK stromal fibroblasts. We found that already starting from the early AK lesions, the dermal expression of FGFR2c is upregulated and accompanied by: (i) the repression o...
Autores principales: | Guttieri, Luisa, Raffa, Salvatore, Salerno, Gerardo, Bigi, Rachele, Persechino, Flavia, Visco, Vincenzo, Torrisi, Maria Rosaria, Ranieri, Danilo, Belleudi, Francesca |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045898/ https://www.ncbi.nlm.nih.gov/pubmed/36979155 http://dx.doi.org/10.3390/biology12030463 |
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