IDH2 Deficiency Promotes Endothelial Senescence by Eliciting miR-34b/c-Mediated Suppression of Mitophagy and Increased ROS Production

Endothelial senescence impairs vascular function and thus is a primary event of age-related vasculature diseases. Isocitrate dehydrogenase 2 (IDH2) plays an important role in inducing alpha-ketoglutarate (α-KG) production and preserving mitochondrial function. However, the mechanism and regulation o...

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Detalles Bibliográficos
Autores principales: Lee, Ikjun, Piao, Shuyu, Kim, Seonhee, Nagar, Harsha, Choi, Su-jeong, Kim, Minsoo, Vu, Giang-Huong, Jeon, Byeong-Hwa, Kim, Cuk-Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045915/
https://www.ncbi.nlm.nih.gov/pubmed/36978833
http://dx.doi.org/10.3390/antiox12030585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045915/
https://www.ncbi.nlm.nih.gov/pubmed/36978833
http://dx.doi.org/10.3390/antiox12030585

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