Cargando…

Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy

Signaling by cAMP is organized in multiple distinct subcellular nanodomains regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic signaling has served as the prototypical system to elucidate cAMP compartmentalization. Although studies in cardiac myocytes have provided an unde...

Descripción completa

Detalles Bibliográficos
Autores principales:	Subramaniam, Gunasekaran, Schleicher, Katharina, Kovanich, Duangnapa, Zerio, Anna, Folkmanaite, Milda, Chao, Ying-Chi, Surdo, Nicoletta C., Koschinski, Andreas, Hu, Jianshu, Scholten, Arjen, Heck, Albert J.R., Ercu, Maria, Sholokh, Anastasiia, Park, Kyung Chan, Klussmann, Enno, Meraviglia, Viviana, Bellin, Milena, Zanivan, Sara, Hester, Svenja, Mohammed, Shabaz, Zaccolo, Manuela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045983/ https://www.ncbi.nlm.nih.gov/pubmed/36883446 http://dx.doi.org/10.1161/CIRCRESAHA.122.321448

Ejemplares similares

Using the Proteomics Toolbox to Resolve Topology and Dynamics of Compartmentalized cAMP Signaling
por: Kovanich, Duangnapa, et al.
Publicado: (2023)

Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System
por: Ercu, Maria, et al.
Publicado: (2018)

Regulation of cardiac function by cAMP nanodomains
por: Folkmanaite, Milda, et al.
Publicado: (2023)

Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes
por: Fields, Laura A., et al.
Publicado: (2016)

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome
por: Terrin, Anna, et al.
Publicado: (2012)

Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the mdx Model of Duchenne Muscular Dystrophy
por: Brescia, Marcella, et al.
Publicado: (2020)

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy
por: Lobo, Miguel J., et al.
Publicado: (2020)

Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling
por: Koschinski, Andreas, et al.
Publicado: (2017)

Subcellular Organization of the cAMP Signaling Pathway
por: Zaccolo, Manuela, et al.
Publicado: (2021)

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains
por: Bolger, Graeme B., et al.
Publicado: (2015)

Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling
por: Vandenwijngaert, Sara, et al.
Publicado: (2013)

Computational Modeling and Numerical Methods for Spatiotemporal Calcium Cycling in Ventricular Myocytes
por: Nivala, Michael, et al.
Publicado: (2012)

Activation of PDE10 and PDE11
por: Jäger, Ronald, et al.
Publicado: (2011)

Duox is the primary NADPH oxidase responsible for ROS production during adult caudal fin regeneration in zebrafish
por: Chopra, Kunal, et al.
Publicado: (2023)

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling
por: Monterisi, Stefania, et al.
Publicado: (2017)

cAMP Compartmentalisation in Human Myometrial Cells
por: Varley, Alice, et al.
Publicado: (2023)

Inflammation in the Pathogenesis of Arrhythmogenic Cardiomyopathy: Secondary Event or Active Driver?
por: Meraviglia, Viviana, et al.
Publicado: (2021)

Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons
por: Chay, Andrew, et al.
Publicado: (2016)

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
por: Omar, Faisa, et al.
Publicado: (2019)

It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3
por: Menges, Lukas, et al.
Publicado: (2023)

Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems
por: Sivakumar, Dakshinamurthy, et al.
Publicado: (2021)

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
por: Surdo, Nicoletta C., et al.
Publicado: (2017)

Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation
por: Vang, Amanda G., et al.
Publicado: (2016)

Geometric methods in PDE’s
por: Citti, Giovanna, et al.
Publicado: (2015)

Optimization with PDE constraints
por: Pinnau, Rene, et al.
Publicado: (2008)

PDE3 is the major cGMP-PDE in adult mouse ventricular cardiomyocytes
por: Götz, Konrad R, et al.
Publicado: (2013)

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway
por: Sachs, Benjamin D., et al.
Publicado: (2007)

Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development
por: Kayık, Gülru, et al.
Publicado: (2017)

HDAC Inhibition Improves the Sarcoendoplasmic Reticulum Ca(2+)-ATPase Activity in Cardiac Myocytes
por: Meraviglia, Viviana, et al.
Publicado: (2018)

Role of Phosphodiesterase 7 (PDE7) in T Cell Activity. Effects of Selective PDE7 Inhibitors and Dual PDE4/7 Inhibitors on T Cell Functions
por: Szczypka, Marianna
Publicado: (2020)

The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells—a Potential Target for Pharmacological Intervention in Cardiovascular Diseases
por: Vukićević, Tanja, et al.
Publicado: (2016)

Frontiers in PDE-constrained optimization
por: Antil, Harbir, et al.
Publicado: (2018)

Numerical PDE-constrained optimization
por: De los Reyes, Juan Carlos
Publicado: (2015)

Trends in PDE constrained optimization
por: Leugering, Günter, et al.
Publicado: (2014)

Pseudodifferential operators and nonlinear PDE
por: Taylor, Michael E
Publicado: (1991)

Control and optimization with PDE constraints
por: Bredies, Kristian, et al.
Publicado: (2013)

Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)
por: Coleman, D. Jackson, et al.
Publicado: (2020)

A Yeast-Based Chemical Screen Identifies a PDE Inhibitor That Elevates Steroidogenesis in Mouse Leydig Cells via PDE8 and PDE4 Inhibition
por: Demirbas, Didem, et al.
Publicado: (2013)

PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts
por: Blackman, Brigitte E., et al.
Publicado: (2011)

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes
por: Pavlaki, Nikoleta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_25lssie1n43iu45dvljqs5il6v