Rapamycin Treatment Alleviates Chronic GVHD-Induced Lupus Nephritis in Mice by Recovering IL-2 Production and Regulatory T Cells While Inhibiting Effector T Cells Activation

In this study, we test the therapeutic effects of rapamycin in a murine model of SLE-like experimental lupus nephritis induced by chronic graft-versus-host disease (cGVHD). Our results suggest that rapamycin treatment reduced autoantibody production, inhibited T lymphocyte and subsequent B cell acti...

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Detalles Bibliográficos
Autores principales: Zhang, Jilu, Wang, Xun, Wang, Renxi, Chen, Guojiang, Wang, Jing, Feng, Jiannan, Li, Yan, Yu, Zuyin, Xiao, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045991/
https://www.ncbi.nlm.nih.gov/pubmed/36979928
http://dx.doi.org/10.3390/biomedicines11030949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045991/
https://www.ncbi.nlm.nih.gov/pubmed/36979928
http://dx.doi.org/10.3390/biomedicines11030949

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