Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies toward JAG1-Positive Tumors

The Notch signaling ligand JAG1 is overexpressed in various aggressive tumors and is associated with poor clinical prognosis. Hence, therapies targeting oncogenic JAG1 hold great potential for the treatment of certain tumors. Here, we report the identification of specific anti-JAG1 single-chain vari...

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Detalles Bibliográficos
Autores principales: Silva, Gabriela, Rodrigues, Ana F., Ferreira, Susana, Matos, Carolina, Eleutério, Rute P., Marques, Gonçalo, Kucheryava, Khrystyna, Lemos, Ana R., Sousa, Pedro M. F., Castro, Rute, Barbas, Ana, Simão, Daniel, Alves, Paula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046313/
https://www.ncbi.nlm.nih.gov/pubmed/36979394
http://dx.doi.org/10.3390/biom13030459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046313/
https://www.ncbi.nlm.nih.gov/pubmed/36979394
http://dx.doi.org/10.3390/biom13030459

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