Structural and Dynamic Differences between Calreticulin Mutants Associated with Essential Thrombocythemia

Essential thrombocythemia (ET) is a blood cancer. ET is characterized by an overproduction of platelets that can lead to thrombosis formation. Platelet overproduction occurs in megakaryocytes through a signaling pathway that could involve JAK2, MPL, or CALR proteins. CALR mutations are associated wi...

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Detalles Bibliográficos
Autores principales: Radjasandirane, Ragousandirane, de Brevern, Alexandre G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046389/
https://www.ncbi.nlm.nih.gov/pubmed/36979444
http://dx.doi.org/10.3390/biom13030509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046389/
https://www.ncbi.nlm.nih.gov/pubmed/36979444
http://dx.doi.org/10.3390/biom13030509

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