Cargando…
The First-In-Class Anti-AXL×CD3ε Pronectin™-Based Bispecific T-Cell Engager Is Active in Preclinical Models of Human Soft Tissue and Bone Sarcomas
SIMPLE SUMMARY: Sarcomas are a group of heterogeneous diseases with a poor prognosis and scarce therapeutic options. Innovative approaches based on novel therapeutic targets are eagerly awaited. AXL, a TAM family tyrosine kinase receptor, recently emerged as an interesting target for several type of...
Autores principales: | Polerà, Nicoletta, Mancuso, Antonia, Riillo, Caterina, Caracciolo, Daniele, Signorelli, Stefania, Grillone, Katia, Ascrizzi, Serena, Hokanson, Craig A., Conforti, Francesco, Staropoli, Nicoletta, Gervasi, Luigia, Di Martino, Maria Teresa, Arbitrio, Mariamena, Nisticò, Giuseppe, Crea, Roberto, Tagliaferri, Pierosandro, Juli, Giada, Tassone, Pierfrancesco |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046451/ https://www.ncbi.nlm.nih.gov/pubmed/36980534 http://dx.doi.org/10.3390/cancers15061647 |
Ejemplares similares
-
A Pronectin™ AXL-targeted first-in-class bispecific T cell engager (pAXLxCD3ε) for ovarian cancer
por: Riillo, Caterina, et al.
Publicado: (2023) -
miRNAs and lncRNAs as Novel Therapeutic Targets to Improve Cancer Immunotherapy
por: Di Martino, Maria Teresa, et al.
Publicado: (2021) -
miR-22 Modulates Lenalidomide Activity by Counteracting MYC Addiction in Multiple Myeloma
por: Caracciolo, Daniele, et al.
Publicado: (2021) -
The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma
por: Grillone, Katia, et al.
Publicado: (2022) -
TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma
por: Scionti, Francesca, et al.
Publicado: (2023)