Cargando…

Computational Analysis and Experimental Testing of the Molecular Mode of Action of Gatastatin and Its Derivatives

SIMPLE SUMMARY: The glaziovianin A derivative gatastatin, presented as a γ-tubulin-specific inhibitor, could represent a viable chemotherapeutic strategy to solve the specificity issues associated with targeting α and β tubulin. Since gatastatin’s specificity for γ tubulin has not been confirmed by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vottero, Paola, Wang, Qian, Michalak, Marek, Aminpour, Maral, Tuszynski, Jack Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046562/ https://www.ncbi.nlm.nih.gov/pubmed/36980600 http://dx.doi.org/10.3390/cancers15061714

Ejemplares similares

Computational Prediction and Experimental Validation of the Unique Molecular Mode of Action of Scoulerine
por: Moshari, Mahshad, et al.
Publicado: (2022)

Computational Prediction of the Interaction of Ivermectin with Fibrinogen
por: Vottero, Paola, et al.
Publicado: (2023)

An Overview of Molecular Modeling for Drug Discovery with Specific Illustrative Examples of Applications
por: Aminpour, Maral, et al.
Publicado: (2019)

New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking
por: Krzywik, Julia, et al.
Publicado: (2020)

How COVID-19 Hijacks the Cytoskeleton: Therapeutic Implications
por: Aminpour, Maral, et al.
Publicado: (2022)

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle
por: Chinen, Takumi, et al.
Publicado: (2015)

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents
por: Krzywik, Julia, et al.
Publicado: (2020)

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19
por: Aminpour, Maral, et al.
Publicado: (2021)

Tubulin Polarizability in Aqueous Suspensions
por: Guzman-Sepulveda, Jose Rafael, et al.
Publicado: (2019)

In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand
por: Pallante, Lorenzo, et al.
Publicado: (2020)

Computational Study of Potential Galectin-3 Inhibitors in the Treatment of COVID-19
por: Aminpour, Maral, et al.
Publicado: (2021)

Tyrosine Kinase Inhibitors Reduce Glucose Uptake by Binding to an Exofacial Site on hGLUT‐1: Influence on (18)F‐FDG PET Uptake
por: Damaraju, Vijaya L., et al.
Publicado: (2021)

The Molecular Mechanism of Action of the CR6261-Azichromycin Combination Found through Computational Analysis
por: Cui, Wei, et al.
Publicado: (2012)

A Novel Interaction Between the TLR7 and a Colchicine Derivative Revealed Through a Computational and Experimental Study
por: Gentile, Francesco, et al.
Publicado: (2018)

The molecular mechanism of action of methylene quinuclidinone and its effects on the structure of p53 mutants
por: Omar, Sara Ibrahim, et al.
Publicado: (2018)

ON THE MODE OF ACTION OF SULFANILAMIDE IN EXPERIMENTAL STREPTOCOCCUS EMPYEMA
por: Gay, Frederick P., et al.
Publicado: (1937)

Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives
por: Wang, Dongdong, et al.
Publicado: (2015)

Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action
por: Tuszynski, Jack A., et al.
Publicado: (2022)

Comparison of Antibacterial Mode of Action of Silver Ions and Silver Nanoformulations With Different Physico-Chemical Properties: Experimental and Computational Studies
por: Kędziora, Anna, et al.
Publicado: (2021)

An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields
por: Tuszynski, Jack A., et al.
Publicado: (2016)

Molecular Insights in Psychiatry
por: Traina, Giovanna, et al.
Publicado: (2022)

Do you really want to deactivate your sacral neuromodulation device during pregnancy? A single center case series
por: Agnello, Marco, et al.
Publicado: (2020)

Sacral neuromodulation to treat voiding dysfunction in patients with previous pelvic surgery for deep infiltrating endometriosis: our centre's experience
por: Agnello, Marco, et al.
Publicado: (2020)

Molecular Insights into the Mode of Action of Antibacterial Peptides Derived from Chicken Plasma Hydrolysates
por: Tian, Fu, et al.
Publicado: (2022)

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives
por: Majcher, Urszula, et al.
Publicado: (2018)

In Vitro Anti-Candida Activity and Action Mode of Benzoxazole Derivatives
por: Staniszewska, Monika, et al.
Publicado: (2021)

Computer-aided design of magnetic molecularly imprinted polymer nanoparticles for solid-phase extraction and determination of levetiracetam in human plasma
por: Attallah, Olivia A., et al.
Publicado: (2018)

Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective
por: Rezania, Vahid, et al.
Publicado: (2020)

Computational Investigation of the Ordered Water System Around Microtubules: Implications for Protein Interactions
por: Chierici, Francesco, et al.
Publicado: (2022)

On the Mode of Action of Strychnia
Publicado: (1868)

On the Mode of Action of Strychnia
por: Spence, Alexander Ingram
Publicado: (1866)

A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives
por: Ebenezer, Oluwakemi, et al.
Publicado: (2022)

A Computational Strategy to Select Optimized Protein Targets for Drug Development toward the Control of Cancer Diseases
por: Carels, Nicolas, et al.
Publicado: (2015)

Wake and higher order mode computations for the CMS experimental chamber at the LHC
por: Wanzenberg, R, et al.
Publicado: (2009)

Editorial: TNFRSF agonists: mode of action and therapeutic opportunities
por: Obermajer, Nataša, et al.
Publicado: (2023)

Special Issue on Molecular Biology and Biophysics of Eukaryotic Cells
por: Ashrafuzzaman, Mohammad, et al.
Publicado: (2015)

Molecular Mode of Action of Asteriscus graveolens as an Anticancer Agent
por: Tayeh, Zainab, et al.
Publicado: (2018)

Acetylcholinesterase in Biofouling Species: Characterization and Mode of Action of Cyanobacteria-Derived Antifouling Agents
por: Almeida, Joana R., et al.
Publicado: (2015)

Tracking the Fate of Muscle-derived Stem Cells: an Insight into the Distribution and Mode of Action
por: Park, Hyung Sub, et al.
Publicado: (2014)

Plant-Derived Inhibitors of AHL-Mediated Quorum Sensing in Bacteria: Modes of Action
por: Deryabin, Dmitry, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_e1uooit9457rdf1cpj6sgrrv02