Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies

SIMPLE SUMMARY: Human RAD52 is a non-essential DNA/RNA-binding protein thought to be involved in many DNA repair mechanisms. Initially regarded as having a major role only in error-prone backup DNA repair mechanisms, RAD52 has recently gained attention because its inhibition induces synthetic lethal...

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Detalles Bibliográficos
Autores principales: Balboni, Beatrice, Rinaldi, Francesco, Previtali, Viola, Ciamarone, Andrea, Girotto, Stefania, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046612/
https://www.ncbi.nlm.nih.gov/pubmed/36980703
http://dx.doi.org/10.3390/cancers15061817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046612/
https://www.ncbi.nlm.nih.gov/pubmed/36980703
http://dx.doi.org/10.3390/cancers15061817

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