Evolutionary Origin of MUTYH Germline Pathogenic Variations in Modern Humans

MUTYH plays an essential role in preventing oxidation-caused DNA damage. Pathogenic germline variations in MUTYH damage its function, causing intestinal polyposis and colorectal cancer. Determination of the evolutionary origin of the variation is essential to understanding the etiological relationsh...

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Detalles Bibliográficos
Autores principales: Xiao, Fengxia, Li, Jiaheng, Lagniton, Philip Naderev Panuringan, Kou, Si Hoi, Lei, Huijun, Tam, Benjamin, Wang, San Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046817/
https://www.ncbi.nlm.nih.gov/pubmed/36979362
http://dx.doi.org/10.3390/biom13030429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046817/
https://www.ncbi.nlm.nih.gov/pubmed/36979362
http://dx.doi.org/10.3390/biom13030429

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