Molecular Analysis of the Superior Efficacy of a Dual Epidermal Growth Factor Receptor (EGFR)-DNA-Targeting Combi-Molecule in Comparison with Its Putative Prodrugs 6-Mono-Alkylamino- and 6,6-Dialkylaminoquinazoline in a Human Osteosarcoma Xenograft Model

Background: ZR2002 is a dual EGFR-DNA-targeting combi-molecule that carries a chloroethyl group at the six-position of the quinazoline ring designed to alkylate DNA. Despite its good pharmacokinetics, ZR2002 is metabolized in vivo into dechlorinated metabolites, losing the DNA-alkylating function re...

Descripción completa

Detalles Bibliográficos
Autores principales: Facchin, Caterina, Fraga-Timiraos, Ana B., Schmitt, Julie, Babaa, Nadia, Pannu, Naveet, Aliaga, Antonio, Larroque, Anne-Laure, Jean-Claude, Bertrand J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046901/
https://www.ncbi.nlm.nih.gov/pubmed/36980255
http://dx.doi.org/10.3390/cells12060914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046901/
https://www.ncbi.nlm.nih.gov/pubmed/36980255
http://dx.doi.org/10.3390/cells12060914

Ejemplares similares