High-Throughput Screening Assay for Detecting Drug-Induced Changes in Synchronized Neuronal Oscillations and Potential Seizure Risk Based on Ca(2+) Fluorescence Measurements in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neuronal 2D and 3D Cultures

Drug-induced seizure liability is a significant safety issue and the basis for attrition in drug development. Occurrence in late development results in increased costs, human risk, and delayed market availability of novel therapeutics. Therefore, there is an urgent need for biologically relevant, in...

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Detalles Bibliográficos
Autores principales: Lu, Hua-Rong, Seo, Manabu, Kreir, Mohamed, Tanaka, Tetsuya, Yamoto, Rie, Altrocchi, Cristina, van Ammel, Karel, Tekle, Fetene, Pham, Ly, Yao, Xiang, Teisman, Ard, Gallacher, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046961/
https://www.ncbi.nlm.nih.gov/pubmed/36980298
http://dx.doi.org/10.3390/cells12060958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046961/
https://www.ncbi.nlm.nih.gov/pubmed/36980298
http://dx.doi.org/10.3390/cells12060958

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