ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition

The rare SLC30A8 mutation encoding a truncating p.Arg138* variant (R138X) in zinc transporter 8 (ZnT8) is associated with a 65% reduced risk for type 2 diabetes. To determine whether ZnT8 is required for beta cell development and function, we derived human pluripotent stem cells carrying the R138X m...

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Detalles Bibliográficos
Autores principales: Sui, Lina, Du, Qian, Romer, Anthony, Su, Qi, Chabosseau, Pauline L., Xin, Yurong, Kim, Jinrang, Kleiner, Sandra, Rutter, Guy A., Egli, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047077/
https://www.ncbi.nlm.nih.gov/pubmed/36980244
http://dx.doi.org/10.3390/cells12060903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047077/
https://www.ncbi.nlm.nih.gov/pubmed/36980244
http://dx.doi.org/10.3390/cells12060903

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