Cargando…

ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition

The rare SLC30A8 mutation encoding a truncating p.Arg138* variant (R138X) in zinc transporter 8 (ZnT8) is associated with a 65% reduced risk for type 2 diabetes. To determine whether ZnT8 is required for beta cell development and function, we derived human pluripotent stem cells carrying the R138X m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sui, Lina, Du, Qian, Romer, Anthony, Su, Qi, Chabosseau, Pauline L., Xin, Yurong, Kim, Jinrang, Kleiner, Sandra, Rutter, Guy A., Egli, Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047077/ https://www.ncbi.nlm.nih.gov/pubmed/36980244 http://dx.doi.org/10.3390/cells12060903

Ejemplares similares

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia
por: Solomou, Antonia, et al.
Publicado: (2016)

Angiotensin II Requires Zinc and Downregulation of the Zinc Transporters ZnT3 and ZnT10 to Induce Senescence of Vascular Smooth Muscle Cells
por: Patrushev, Nikolay, et al.
Publicado: (2012)

ZnT8 Haploinsufficiency Impacts MIN6 Cell Zinc Content and β-Cell Phenotype via ZIP-ZnT8 Coregulation
por: Lawson, Rebecca, et al.
Publicado: (2019)

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance
por: Mitchell, Ryan K., et al.
Publicado: (2016)

Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients
por: Skärstrand, H, et al.
Publicado: (2015)

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells
por: Gerber, Philipp A., et al.
Publicado: (2014)

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells
por: Bin, Bum-Ho, et al.
Publicado: (2018)

Importance of Both Imprinted Genes and Functional Heterogeneity in Pancreatic Beta Cells: Is There a Link?
por: Chabosseau, Pauline, et al.
Publicado: (2021)

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
por: Dwivedi, Om Prakash, et al.
Publicado: (2019)

Alterations in ZnT1 expression and function lead to impaired intracellular zinc homeostasis in cancer
por: Lehvy, Adrian Israel, et al.
Publicado: (2019)

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion
por: Solomou, Antonia, et al.
Publicado: (2015)

Insights into the Dynamics of the Human Zinc Transporter ZnT8 by MD Simulations
por: Sala, Davide, et al.
Publicado: (2021)

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons
por: Wang, Liheng, et al.
Publicado: (2017)

Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death
por: Karsai, Maria, et al.
Publicado: (2022)

OR02-01 Somatic Mutations In The Zinc Transporter ZnT1 Cause Primary Aldosteronism
por: Rege, Juilee, et al.
Publicado: (2023)

Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway
por: Fujimoto, Shigeyuki, et al.
Publicado: (2013)

ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice
por: Podany, Abigail B., et al.
Publicado: (2016)

Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression
por: Wagatsuma, Takumi, et al.
Publicado: (2022)

Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
por: Howson, J. M. M., et al.
Publicado: (2012)

Demonstrating aspects of multiscale modeling by studying the permeation pathway of the human ZnT2 zinc transporter
por: Golan, Yarden, et al.
Publicado: (2018)

Why and how to investigate the role of protein phosphorylation in ZIP and ZnT zinc transporter activity and regulation
por: Thingholm, T. E., et al.
Publicado: (2020)

Association of Zinc Transporter-8 Autoantibody (ZnT8A) with Type 1 Diabetes Mellitus
por: Bhatty, Afreen, et al.
Publicado: (2020)

Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn(2+) uptake into the Golgi apparatus
por: Bui, Han Ba, et al.
Publicado: (2023)

Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouse
por: Niu, Li, et al.
Publicado: (2020)

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1
por: Krall, Rebecca F., et al.
Publicado: (2020)

The C‐terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant
por: Parsons, Douglas S., et al.
Publicado: (2018)

Correction: Demonstrating aspects of multiscale modeling by studying the permeation pathway of the human ZnT2 zinc transporter
por: Golan, Yarden, et al.
Publicado: (2019)

Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions
por: Catapano, Maria Carmen, et al.
Publicado: (2021)

Altered Expression of ZnT10 in Alzheimer's Disease Brain
por: Bosomworth, Helen J., et al.
Publicado: (2013)

The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective
por: Kimura, Tomoki, et al.
Publicado: (2016)

Neuroprotective Effect of ZnT3 Knockout on Subarachnoid Hemorrhage
por: Chen, Duo, et al.
Publicado: (2018)

Genetic, Functional, and Immunological Study of ZnT8 in Diabetes
por: Huang, Qiong, et al.
Publicado: (2019)

Development of an immunoassay for the simultaneous detection of GADA and ZnT8A in autoimmune diabetes using a ZnT8/GAD65 chimeric molecule
por: Trabucchi, Aldana, et al.
Publicado: (2023)

The Role of ZntA in Klebsiella pneumoniae Zinc Homeostasis
por: Maunders, Eve A., et al.
Publicado: (2022)

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
por: Nicolson, Tamara J., et al.
Publicado: (2009)

Differential Subcellular Localization of the Splice Variants of the Zinc Transporter ZnT5 Is Dictated by the Different C-Terminal Regions
por: Thornton, Jared K., et al.
Publicado: (2011)

Neurochemical Characterization of Zinc Transporter 3-Like Immunoreactive (ZnT3(+)) Neurons in the Intramural Ganglia of the Porcine Duodenum
por: Wojtkiewicz, Joanna, et al.
Publicado: (2012)

Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation
por: Yoo, Min Heui, et al.
Publicado: (2016)

Zinc transporter 8 (ZnT8) autoantibody prevalence in black South African participants with type 1 diabetes
por: Bhola, Sureka, et al.
Publicado: (2021)

Expression profile of the zinc transporter ZnT3 in taste cells of rat circumvallate papillae and its role in zinc release, a potential mechanism for taste stimulation
por: Nishida, Kentaro, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_inf0p1uggo9fs5qrck85bkstbv