Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma

Mitophagy plays an important role in maintaining mitochondrial homeostasis by clearing damaged mitochondria. Sphingosine kinase 2 (SK2), a type of sphingosine kinase, is an important metabolic enzyme involved in generating sphingosine-1-phosphate. Its expression level is elevated in many cancers and...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Jian, Fan, Shengjun, Feinberg, Daniel, Wang, Xiaobei, Jabbar, Shaima, Kang, Yubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047154/
https://www.ncbi.nlm.nih.gov/pubmed/36975444
http://dx.doi.org/10.3390/curroncol30030231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047154/
https://www.ncbi.nlm.nih.gov/pubmed/36975444
http://dx.doi.org/10.3390/curroncol30030231

Ejemplares similares