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Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma
Mitophagy plays an important role in maintaining mitochondrial homeostasis by clearing damaged mitochondria. Sphingosine kinase 2 (SK2), a type of sphingosine kinase, is an important metabolic enzyme involved in generating sphingosine-1-phosphate. Its expression level is elevated in many cancers and...
Autores principales: | Wu, Jian, Fan, Shengjun, Feinberg, Daniel, Wang, Xiaobei, Jabbar, Shaima, Kang, Yubin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047154/ https://www.ncbi.nlm.nih.gov/pubmed/36975444 http://dx.doi.org/10.3390/curroncol30030231 |
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